糖心视频

Seminar Abstract: Precise temporal and spatial regulation of cell cycle progression is required for both development and maintenance of adult tissue. Cell adhesion to the extracellular matrix (ECM), mediated by integrin-dependent adhesion complexes (ACs), is required for cell survival and cell cycle progression. The ability of cancer cells to evade this requirement has long been a hallmark of tumour development. Rounding up of cells occurs during mitosis, which requires the coordinated disassembly of ACs, before they are reestablished following cytokinesis. Therefore, a reciprocal regulation exists between ECM adhesion and cell cycle progression. Failure of this inter-dependence of adhesion and cell cycle progression results in aberrant cell division, contributing to the progression of several diseases. At present, it is unclear how integrin and cell cycle signalling are coordinated to ensure accurate cell division. ACs change in composition as cells progress through the cell cycle in a CDK1-dependent manner, with an increase in AC area being observed in S-phase followed by a decrease in adhesion area in G2 prior to complete AC disassembly in mitosis. However, it remains unclear how S-phase adhesion growth is promoted or what the functional consequence of this on cell cycle progression is. Preliminary work indicates that S-phase adhesion growth is a consequence of DNA replication rather than a driving force for progression through S-phase, with perturbation of adhesion growth resulting in a prolonged S-phase and delay in G2 entry. These data identify a novel role for adhesion signalling in promoting the S-G2 transition and describe a mechanism of replication-dependent reverse mechanotransduction that link DNA compaction to changes in the cytoskeleton and adhesions.

Biosketch: Dr Matt Jones is a Lecturer in Cancer Biology at the Peninsula Medical School, University of Plymouth, UK, where he co-leads the Microenvironment and Matrix Research Group.

His research focuses on understanding how interactions between cells and the extracellular matrix regulate cell behaviour, particularly in cancer. He investigates the molecular mechanisms linking cell adhesion, integrin signalling and cell cycle regulation to cancer cell proliferation, migration and invasion. His work has explored how cell cycle regulators, including cyclin-CDK1 complexes, influence cell migration and tumour invasiveness.

Through his research, Dr Jones aims to advance our understanding of tumour progression and identify potential opportunities for therapeutic intervention. He also contributes to teaching in cell and cancer biology and serves as an Associate Editor of Cell Adhesion & Migration.